서울대 박중훈

Project 01

Knowledge-based identification of novel genes of metabolic traits

Skeletal muscle and adipose tissues, the target organs of the metabolic phenotype, are directly related to various metabolic disorders such as obesity, diabetes, dyslipidemia and hypertension, and the economic traits of livestock. Based on bioinformatics and nonclinical approaches, this project aims to find the causative genes determining the metabolic phenotypes and to elucidate the molecular functions of them. This will prompt new therapeutic options and enhancement of livestock product competitiveness.

▷ Key words: Metabolic disorders, Therapeutic target, Nonclinical target validation, Bioinformatics

Project 02

Role of Prokr1 in myogenesis and insulin resistance

Prokineticin Receptor 1 (Gpr73), one of candidate genes identifiedfrom knowledge-based identification of novel genes of metabolic traits project,has been reported to regulate metabolic phenotypes through the effects on adipocytedifferentiation and vascular structure. To investigate the role of Prokr1 in skeletalmuscle, we evaluate its effects on muscular satellite cell proliferation andmyotube differentiation, and insulin resistance. Furthermore, we seek novelProkr1 modulators through drug repositioning approach.

▷ Key words: Prokr1,Pk2, skeletal muscle, muscular satellite cell, insulin resistance

Project 03

Therapeutic microvesicle production through 3D culture of hMSCs

Microvesicles secreted from cells are recognized as the majormediators of intercellular signaling and have demonstrated widespreadpharmacological efficacy. This study aims to induce the characteristic changeof human mesenchymal stem cells through the 3D culture using a novel polymer,and to mass produce and characterize microvesicles whether having increasedtherapeutic potency.

▷ Key words: Microvesicle, polymer for 3D culture, human mesenchymal stem cells

Project 04

Therapeutic mechanism study through integrative transcriptome analyses

The transcript profile observed in cells or animal tissues is used as a primary means to understand the mechanism of action of small molecular or genetic pertubegens. This study promotes the development of drug candidates by identifying the signaling pathways and pharmacological targets of new drug candidates through integrative analysis of transcriptome and phenotypes and drug-target association. In addition, the molecular mechanism of the gene of interest is understood through the association analysis of the transcriptional profile obtained through the loss- or gain-of-function of the target gene, and a candidate substance which can modulate its activity is discovered.

▷ Key words: Transcriptome, signaling pathways, therapeutic targets, drug candidates

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서울대 박중훈 Systems Pharmacology Lab

Project